Research Interests:

• Convergence analysis of modern iterative methods, in particular Krylov subspace methods for the solution of linear systems and eigenproblems with nonnormal matrices

• Preconditioning and sparse direct solvers for linear systems

• Implementations and matrix computations in statistical methods

• Mathematical modeling in pharmacology

Recent projects, grants:

• Principal investigator of the 4EU+ alliance project ,,Improved modeling and simulation of drugs metabolism with spatial resolution for patient-taylored pharmacotherapy" (project number 4EU+/21/F1/05 granted by Charles University). Duration: 2021.

• Principal investigator of the 4EU+ alliance project ,,Efficient spatio-temporal modeling and simulation of drugs metabolism for patient-taylored pharmacotherapy" (project number 4EU+/20/F1/9 granted by Charles University). Duration: 2020.

• Principal investigator of the 4EU+ alliance kick-off project ,,Spatio-temporal modeling and simulation of drugs metabolism for enhanced pharmaco-therapy" (project number 4EU+/19/10 granted by Charles University). Duration: 2019.

• Member of the project ,,Novel interventions for the treatment of triglycerides, cholesterol and bile acids diseases with human CAR ligands", grant GA19-14497S of the grant agency of the Czech Republic. Duration: 2019-2021.

• Supervisor for the student's grant ,,PKPD modeling of rifampicin distribution with spatial resolution and its possible clinical implications", grant project 898918 of the grant agency of Charles University, (principal investigator Andreas Matthios). Duration: 2018-2020.

• Member of the project ,,Dynamics of nuclear receptor-mediated gene regulation:implement for the understanding of detoxification functions and optimization of therapy", grant GA17-06841S of the grant agency of the Czech Republic. Duration: 2017-2019.

• Supervisor for the student's grant ,,Mixed PDE/ODE modeling of drug distribution profiles for efficient pharmacotherapy", grant project 1206517 of the grant agency of Charles University, (principal investigator Malek Azar). Duration: 2017-2019.

• Member of the ,,Necas Center".

• Member of the research group of clinical and molecular pharmacotherapy.

• Member of the project ,,Iteracni metody ve vypocetni matematice: Analyza, predpodmineni a aplikace", grant GA13-06684S of the grant agency of the Czech Republic. Duration: 2013-2017.

• Member of the project ,,Konvergence a urychlovani iteracnich metod pro reseni praktickych aplikaci", project M100301201 of the grant agency of the Academy of Sciences of the Czech Republic). Duration: 2012-2015.

• Member of the Krylov project on the theory of Krylov subspace methods and its relationship to other mathematical disciplines; project number IAA100300802 of the grant agency of the Academy of Sciences of the Czech Republic (Principal investigator: Zdenek Strakos). Duration: 2008 - 2012.

• Member of the project ,,Towards deeper understanding of Krylov subspace methods", project M100300901 of the grant agency of the Academy of Sciences of the Czech Republic). Duration: 2009 - 2012.

• Principal investigator of the young researcher's grant ,,Solution of large, sparse and nonsymmetric linear systems with Krylov subspace methods" (project number KJB100300703 of the Grant Agency of the Academy of Sciences of the Czech Republic). Duration: 2007 - 2009.

• Member of project B17: ,,Improvement of the linear algebra kernel of Simplex-based LP- and MIP-solvers" of the DFG research center MATHEON, Berlin (Principal investigators: Joerg Liesen, Reinhard Nabben and Martin Groetschel.) Duration: August 2006 - January 2007.

• Member of the MSTeP project (Modeling and Simulation of complex TEchnical Problems), project number 1ET400300415 of the Program ,,Information Society'' of the Czech Republic (Principal investigator: Zdenek Strakos). Duration: 2004 - 2008.